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A study of diesel emissions on Drosophila.

Authors
Schuler-RL; Niemeier-RW
Source
Health effects of diesel engine emissions: proceedings of an international symposium, December 3-5, 1979. Pepelko WE, Danner RM, Clarke NA, eds. Cincinnati, OH: U.S. Environmental Protection Agency, EPA-600/9-80-057b, 1980 Nov; 2:914-923
Link
NIOSHTIC No.
00148911
Abstract
The mutagenic effects of diesel exhaust emissions were studied in Drosophila-melanogaster fruit flies. Male Drosophila flies were exposed to a five fold dilution of exhaust from a diesel engine for 8 hours. The flies were allowed to mate. A sex linked recessive lethal study was performed on broods of the F2 and F3 generations. Samples of the atmosphere in the exposure chamber were analyzed. The composition of the exposure chamber atmosphere was: carbon- dioxide (124389), 0.17 percent; carbon-monoxide (630080), 12.2 parts per million (ppm); total hydrocarbons, 11.6ppm; sulfur-dioxide (7446095), 1.0ppm; nitric-oxide (10102439), 3.8ppm; nitrogen-dioxide (10102440), 2.9ppm; and particulates, 2.2 milligrams per cubic meter. The incidence of mutations in the exposed F2 broods was 0.30 percent and in the controls, 0.37 percent. The mutation frequency in the exposed F3 generation was 0 percent and in the controls, 0.15 percent. The overall incidence (F2 plus F3) of mutants was: exposed flies, 0.20 percent; controls, 0.29 percent. The authors conclude that under the conditions of the experiment, diesel exhaust emissions are not mutagenic. They recommend repeating the experiment with higher exposure concentrations and longer exposures.
Keywords
Exhaust-gases; Health-hazards; Health-standards; Exposure-levels; Exhaust-systems; Carcinogenicity; Environmental-pollution; Physiology; Diesel-exhausts; Cancer; Environmental-health-monitoring
CAS No.
124-38-9; 630-08-0; 7446-09-5; 10102-43-9; 10102-44-0
Publication Date
19801101
Document Type
Conference/Symposia Proceedings
Editors
Pepelko-WE; Danner-RM; Clarke-NA
Fiscal Year
1981
NTIS Accession No.
NTIS Price
NIOSH Division
DBBS
Source Name
Health effects of diesel engine emissions: proceedings of an international symposium, December 3-5, 1979
State
OH
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