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Special hazard review of di-2-ethylhexyl phthalate and slternative test agents in respirator quantitative Fit testing.

Authors
NIOSH
Source
NIOSH 1981 Sep; :1-36
Link
NIOSHTIC No.
00148515
Abstract
A NIOSH hazard review of di-2-ethylhexyl-phthalate (117817) (DEHP) and possible alternative test agents used for respiratory quantitative fit testing are presented. The toxicity of DEHP is considered. DEHP has been shown to be toxic only when administered to laboratory animals at high doses. The median lethal doses range from 14.2 to 33.9 grams per kilogram. No definite evidence of teratogenicity or mutagenicity has been found. In bioassays with B6C3F1-mice and female Fischer-344-rats, a treatment related excess incidence of hepatocellular carcinomas occurred. Mechanisms by which DEHP induces liver neoplasms are unclear. Alternative test substances should be substituted for DEHP in respirator quantitative fit testing if feasible. The toxicities of di-2-ethylhexyl-sebacate (122623), dimethyl-polysiloxane (9006659), refined corn oil, and mineral oil are considered. All except mineral oil appear to be suitable as substitutes for DEHP in quantitative fit testing of respirators. Mineral oil is eliminated as it tends to accumulate in lungs. Refined corn oil appears to be the best candidate for replacing DEHP as it has a very low order of toxicity, and extensive negative data on its carcinogenic potential exists.
Keywords
NIOSH-Author; Quantitative-analysis; Industrial-environment; Hazards; Animal-studies; Lethal-concentrations; Carcinogenicity; Physiological-function; Respiratory-equipment; Respiratory-irritants
CAS No.
117-81-7; 122-62-3; 9006-65-9
Publication Date
19810901
Document Type
Other
Fiscal Year
1981
NTIS Accession No.
PB85-243020
NTIS Price
A04
NIOSH Division
DSDTT
Source Name
National Institute for Occupational Safety and Health
State
OH
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