HHE determination report no. HETA-79-109-1538, Kelly Springfield Tire Company, Cumberland, Maryland.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HETA 79-109-1538, 1984 Dec; :1-50
Environmental and breathing zone samples were analyzed for N- nitrosomorpholine (59892) and other nitrosamines at Kelly Springfield Tire Company (SIC-3011), Cumberland, Maryland in July, October, and December, 1979, and January, 1980. The local union requested the evaluation because N-nitrosodiphenylamine (86306) (NDPhA), a retarding agent used during tire manufacture, had been shown to be carcinogenic. Mortality records of all employees who died between 1968 and 1980 were reviewed. The ventilation system was inspected. N-nitrosomorpholine and N-nitrosodimethylamine (62759) were found at concentrations of 1.4 to 248 and 0.05 to 4.1 micrograms per cubic meter (microg/m3), respectively. There are no federal standards for airborne nitrosamines. After the company made NIOSH recommended ventilation improvements and removed NDPhA from the rubber batch mixes, mean N-nitrosomorpholine concentrations decreased to 1 to 2microg/m3. Computed proportionate mortality ratios indicated an excess incidence of mortality from arteriosclerotic heart disease and hematopoietic cancer of other lymph tissues. The authors conclude that a health hazard due to a high N-nitrosomorpholine exposures existed at the facility. The excess hematopoietic and arteriosclerotic heart disease mortality could be work related, but a chance occurrence is possible. Recommendations include ventilation system monitoring and analysis of the causes of mortality among former employees.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; Hazards-Confirmed; Synthetic-rubber-manufacturing; Region-3; Carcinogens; Industrial-chemicals; Mortality-surveys; Disease-incidence; HETA-79-109-1538;
Author Keywords: Tire Manufacture; Nitrosamines; N-nitroso-diphenylamine; N-nitroso-morpholine; N-nitroso-dimethylamine; N-nitroso-pyrrolidine; Hematopoietic Cancer; Arteriosclerotic Heart Disease; n-nitrosodiphenylamine; Tardex; truck tires
59-89-2; 86-30-6; 62-75-9
Field Studies; Hazard Evaluation and Technical Assistance
NTIS Accession No.
National Institute for Occupational Safety and Health