Acute human ventilatory response to card-generated dust from cotton representing reference standard cotton dust.
Castellan-RM; Hankinson-JL; Olenchock-SA; Cocke-JB
Cotton dust: proceedings of the Eighth Cotton Dust Research Conference, beltwide cotton production research conferences, January 9-10, 1984, Atlanta, Georgia. Wakelyn PJ, Jacobs RR, eds. Memphis, TN: The National Cotton Council of America, 1984 Jan; :35-37
Acute human ventilatory response to a reference standard cotton dust was investigated. The cohort consisted of 600 healthy adult volunteers. Cotton dust was generated in two experimental card rooms, and subjects were exposed to cotton dust for 6 hours. Comparisons were subjected to a dust free environment for the same length of time. Ventilatory responses were measured using a spirometer to determine forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) before and after exposure in all subjects. For each exposure, a time weighted average dust concentration was determined. Endotoxin content of dust was determined. Statistical significance of data was assessed by the least squares linear regression method. Mean change in FEV1 at 75 percent of expired vital capacity ranged between minus 16 and minus 23 percent in cotton dust exposed subjects. Values in comparisons ranged between minus 5 to plus 3 percent. Mean change in FVC ranged from minus 1.5 to minus 3 percent for dust exposures and was 0.2 percent for all comparisons. Endotoxin content of airborne cotton dust was about 245 nanograms per milligram. The authors conclude that the cotton dust generated and used in this study contained a substantial amount of foreign agents that are apparently active in human airways.
Industrial-dusts; Airborne-fibers; Aerosol-particles; Biological-effects; Physiological-response; Respiratory-irritants; Lung-irritants; Respirable-dust; Lung-function; Physiological-measurements; Medical-research
Cotton dust: proceedings of the Eighth Cotton Dust Research Conference, beltwide cotton production research conferences, January 9-10, 1984, Atlanta, Georgia