The Occupational Safety and Health Guidance Manual for hazardous waste site activities is presented. The manual was prepared by NIOSH, OSHA, the United States Coast Guard, and the Environmental Protection Agency. The manual is a guidance document for managers responsible for occupational safety and health programs at inactive hazardous waste sites. It assumes a basic knowledge of science and experience in occupational safety and health. The manual is intended for federal, state and local officials, and their contractors. It may be used as a planning tool by government or private individuals, as a management tool by upper managers, as an educational tool to provide a comprehensive overview of all aspects of safety and health protection at hazardous waste sites, and as a reference document for site personnel who need to review important aspects of health and safety. It is noted that although the manual cites federal regulations, it is not a definitive legal document and should not be taken as such. Topics covered include types of hazards encountered at hazardous waste sites, planning and organization, training, medical programs, site characterization, air monitoring, personal protective equipment, site control, decontamination, handling drums and other containers, and dealing with site emergencies.