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An evaluation of reports of dioxin exposure and soft tissue sarcoma pathology among chemical workers in the United States.

Authors
Fingerhut-MA; Halperin-WE; Honchar-PA; Smith-AB; Groth-DH; Russell-WO
Source
Scand J Work, Environ & Health 1984 Oct; 10(5):299-303
NIOSHTIC No.
00145001
Abstract
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (2,3,7,8-TCDD) on soft tissue sarcoma pathology were investigated in exposed workers. Employment records, medical and pathological reports, tissue specimens, and death certificates were obtained for seven potentially exposed workers. Of the seven workers, five had definite exposures to dioxins in a department using 2,4,5- trichlorophenoxyacetic-acid (93765) (2,4,5-T), or trichlorophenol (25167822). Some subjects had records of diagnosed chloracne or dermatitis of the face and neck. Of four subjects with confirmed exposure to 2,3,7,8-TCDD, two had pathologically confirmed soft tissue sarcoma. No definitive conclusions were justified because of lack of a valid comparison group. Different pathologists diagnosed different histological types for the sarcomas evaluated. Death certificates did not show some cases of soft tissue carcinomas that had been diagnosed by hospitals. The authors conclude that evaluating outcome of soft tissue carcinoma is complex. Carefully designed epidemiologic studies are necessary to assess the associations between soft tissue sarcoma and exposure to products contaminated with dioxin. Pathological examination of tissue specimens by sarcoma experts is necessary to accurately identify cases.
Keywords
NIOSH-Author; Industrial-chemicals; Pesticides-and-agricultural-chemicals; Herbicides; Biological-effects; Employee-exposure; Occupational-exposure; Medical-research; Medical-surveys; Toxicopathology; Epidemiology; Clinical-diagnosis
CODEN
SWEHDO
CAS No.
1746-01-6; 93-76-5; 25167-82-2
Publication Date
19841001
Document Type
Journal Article
Fiscal Year
1985
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0355-3140
Source Name
Scandinavian Journal of Work, Environment and Health
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