The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (2,3,7,8-TCDD) on soft tissue sarcoma pathology were investigated in exposed workers. Employment records, medical and pathological reports, tissue specimens, and death certificates were obtained for seven potentially exposed workers. Of the seven workers, five had definite exposures to dioxins in a department using 2,4,5- trichlorophenoxyacetic-acid (93765) (2,4,5-T), or trichlorophenol (25167822). Some subjects had records of diagnosed chloracne or dermatitis of the face and neck. Of four subjects with confirmed exposure to 2,3,7,8-TCDD, two had pathologically confirmed soft tissue sarcoma. No definitive conclusions were justified because of lack of a valid comparison group. Different pathologists diagnosed different histological types for the sarcomas evaluated. Death certificates did not show some cases of soft tissue carcinomas that had been diagnosed by hospitals. The authors conclude that evaluating outcome of soft tissue carcinoma is complex. Carefully designed epidemiologic studies are necessary to assess the associations between soft tissue sarcoma and exposure to products contaminated with dioxin. Pathological examination of tissue specimens by sarcoma experts is necessary to accurately identify cases.