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Carcinogenic Potential Of Condensed Pyrolysis Effluents From Iron Foundry Casting Operations, Volume V.

Authors
Shellenberger-TE; Garner-FM; Plankenhorn-LJ
Source
NIOSH 1984 Oct:211 pages
Link
NIOSHTIC No.
00144931
Abstract
Data tabulations for a carcinogenesis bioassay of condensed effluents from iron foundry casting operations that used hamsters as the test species are presented. In that study, Syrian-golden- hamsters were administered effluents from shell sand, green sand, furan (110009), or urethane (51796) casting molds once a week for 18 weeks by intratracheal instillation. The concentrations were 5 or 10 milligrams (mg) effluent in 0.2 milliliter of distilled water, except for the effluents from the urethane mold, which were administered in amounts of 2.5 or 5.0mg. Benzo(a)pyrene (50328) plus ferric-oxide (1309371) and ferric-oxide alone were administered as positive controls. The animals were maintained until 98 percent mortality occurred or until week 103 in the case of females or week 117 in the case of males. None of the effluents were found to be carcinogenic at the concentrations used. The histopathological results for each individual animals were tabulated. A tumor inventory for each animal was also constructed.
Keywords
NIOSH-Contract; Lung-fibrosis; Iron-working-industry; Data-processing; Iron-oxide-fumes; Equipment-design; Pharmacodynamics; Quantitative-analysis; Pyrolysis; Toxicology; Contract-210-78-0033;
CAS No.
110-00-9; 51-79-6; 50-32-8; 1309-37-1;
Publication Date
19841015
Funding Type
Contract;
Fiscal Year
1985
NTIS Accession No.
PB85-215218
NTIS Price
A11
Identifying No.
Contract-210-78-0033
NIOSH Division
DBBS;
Source Name
Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio
State
OH;
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