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Developmental effects after inhalation exposure of gravid rabbits and rats to ethylene glycol monoethyl ether.

Andrew-FD; Hardin-BD
Environ Health Perspect 1984 Aug; 57:13-23
Possible developmental changes in rabbits and rats exposed to ethylene-glycol-monoethyl-ether (110805) (EGEE) were investigated. Thirty pregnant New-Zealand-white-rabbits were exposed to 160 or 617 parts per million (ppm) EGEE for 7 hours per day from 1 to 18 days of gestation. Thirty virgin Wistar-rats were exposed to 150 or 649ppm EGEE for 5 days per week for the 3 weeks immediately preceding their breeding; in both cases the control animals were exposed to air. Sperm positive rats were exposed to air or 202 or 767ppm EGEE for 7 hours per day. All animals were weighed, and food consumption was measured throughout the studies. Maternal organs were weighed and examined for gross and histopathological changes; reproductive status was determined and uterine contents were examined for fetal mortality, growth retardation, or terata. Pregestational exposure of rats had no effect on mating success, and EGEE had no effect on establishment of pregnancy in either species. Rabbits exposed to EGEE at 160 or 617ppm had decreased food intake and depressed weight gain. Rabbits exposed to EGEE at 617ppm were susceptible to mortality. Rats exposed to EGEE at 767ppm showed reduced weight gain. In both rats and rabbits, exposure to EGEE induced high embryo mortality at maternal toxic concentrations. Lower concentrations induced fetal growth retardation in rats but not in rabbits. Gestational exposure increased the incidence of anomalies and variations, primarily of soft tissues in rabbits and skeletons in rats. The authors conclude that based on the evidence of terata, fetal growth retardation, and embryo mortality in rabbits and rats, EGEE is teratogenic.
NIOSH-Author; Industrial-chemicals; Solvents; Medical-research; Animal-studies; Reproductive-effects; Toxic-vapors; Teratogens; Dose-response; Embryotoxicity; Quantitative-analysis; Histopathology
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Environmental Health Perspectives