Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The effects of carbon disulfide on the reproductive system of the male rat.

Authors
Tepe-SJ; Zenick-H
Source
Toxicology 1984 Jul; 32(1):47-56
NIOSHTIC No.
00142255
Abstract
The reproductive effects of carbon-disulfide (75150) (CS2) were investigated in rats. Male Long-Evans-hooded-rats were used in two experimental protocols. The first group was exposed to 0, 350, or 600 parts per million (ppm) CS2 for 10 weeks prior to sacrifice. Reproductive organ weights, epididymal sperm count, and hormone activities (luteinizing, follicle stimulating, and testosterone) were measured. In protocol 2, after exposure to 600ppm CS2, each animal was mated weekly and coital behavior, ejaculated sperm count, and hormone content were monitored after 0, 1, 4, 7, and 10 weeks of exposure. Epididymal sperm counts were similar in all groups, but were slightly lower in the 600ppm CS2 group. Plasma testosterone content was significantly lower in animals exposed to 600ppm CS2. Mount latencies were significantly reduced after 7 weeks of exposure, while ejaculation latencies were significantly decreased by week 4 of CS2 exposure. A marked decrease in sperm count occurred after 7 weeks of CS2 exposure and remained depressed throughout the 10 weeks of exposure. There were no significant treatment related effects seen in plasma follicle stimulating or luteinizing hormone values. Histologic examination of the testes of animals exposed to 350 or 600ppm CS2 showed no alterations from normal. The authors conclude that CS2 is a toxin of the male reproductive system resulting in abnormal coital behavior and decreased sperm counts.
Keywords
NIOSH-Publication; NIOSH-Grant; Testes; Reproductive-system-disorders; Spermatogenesis; Carbamates; Sulfides; Animal-studies; Rodents; Hormone-activity; Toxic-effects; Biological-effects; Fertility
Contact
Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, Ohio 45267
CODEN
TXCYAC
CAS No.
75-15-0
Publication Date
19840701
Document Type
Journal Article
Funding Amount
218617
Funding Type
Grant
Fiscal Year
1984
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-01272
Issue of Publication
1
ISSN
0300-483X
Priority Area
Reproductive-system-disorders
Source Name
Toxicology
State
ME; OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
TOP