Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Health implications of the Mount St. Helens' eruption: laboratory investigations.

Authors
Green-FH; Bowman-L; Castranova-V; Dollberg-DD; Elliot-JA; Fedan-JS; Hahon-N; Judy-DJ; Major-PC; Mentnech-MS; Miles-PR; Mull-J; Olenchock-S; Ong-T
Source
Ann Occup Hyg, Inhaled Particles V, 1982 Sep; 26(1-4):921-933
NIOSHTIC No.
00139476
Abstract
The mutagenic, fibrogenic, and cytotoxic potential of volcanic ash from the eruption of Mount Saint Helens was assessed, together with the effects on immunological, antiviral, and antibacterial defense mechanisms. The mutagenic potential of the ash was tested by a Salmonella reversion assay and an arabinose resistant forward mutation assay. Interferon induction by ultraviolet irradiated influenza virus was determined in monkey kidney cell monolayers treated with the ash. Cytotoxicity was assayed by culturing rat tracheal tissue in the presence of radiolabeled glucosamine and the ash, and counting the filtrate by liquid scintillation. To determine the fibrogenic properties of the ash, its effect on growth of fetal lung fibroblasts was monitored; the ability of the ash to hemolyze sheep red cells was also studied, as was the effect on macrophages. In-vitro and in-vivo pulmonary effects were assayed. The ash extracts were found to be mildly fibrogenic in-vitro and in- vivo, but they were not mutagenic and had no effect on interferon production. There was some indication that the ash impaired antibacterial host defense mechanisms. The authors conclude that volcanic ash is moderately biologically active and cannot be considered inert.
Keywords
Immunology; Mutagenicity; Carcinogenicity; Cytotoxic-effects; In-vivo-study; In-vitro-study; Biological-effects; Respirable-dust
Contact
Laboratory Investigations Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, U.S.A.
CODEN
AOHYA3
Publication Date
19820901
Document Type
Journal Article
Editors
Walton-WH
Fiscal Year
1982
NTIS Accession No.
NTIS Price
ISBN No.
9780080268385
Issue of Publication
1-4
ISSN
0003-4878
NIOSH Division
DRDS
Source Name
Annals of Occupational Hygiene, Inhaled Particles V
State
WV
TOP