Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Renal tubular handling of zinc in the dog.

Authors
Victery-W; Smith-JM; Vander-AJ
Source
Am J Physiol, Lung Cell Mol Physiol 1981 Nov; 10(5):F532-F539
NIOSHTIC No.
00136924
Abstract
Renal clearance of zinc (7440666) was investigated in dogs. Anesthetized dogs were given catheters of polyethylene tubing in cephalic and femoral veins and one femoral artery. The right ureter was catheterized. Stop flow experiments were performed to determine creatinine clearance and water reabsorption. Dogs were given an infusion containing zinc-65 (13982393) (Zn-65) with various amounts of zinc-chloride (7646857) as carrier. Clearance of Zn-65 was determined. Standard stop flow experiments were conducted. Samples were counted, and creatinine was measured in urine and ultrafiltrable samples. Net reabsorption averaging approximately 95 percent was the dominant tubular mechanism for renal handling of acutely administered zinc. Fractional zinc excretion was significantly elevated. Treatment with chlorothiazide (58946) lowered the ultrafiltrable Zn-65, but increased fractional excretion by about 300 percent. Cysteine (52904) and histidine (71001) infusion elevated the percentage of ultrafiltrable Zn-65 by 20 and 20 times, respectively. The net reabsorption that occurred in the segment corresponding to distal reabsorptive minimum for sodium was strikingly increased for Zn-65 in stop flow patterns. Proximal reabsorption of zinc was not obvious in normal stop flow patterns. The authors conclude that the combination of clearance and stop flow techniques reveals that the amount of zinc excreted is normally the result of filtration and reabsorption. Chlorothiazide induces far distal secretion, and citrate and amino acids influence infiltration and reabsorption.
Keywords
NIOSH-Publication; NIOSH-Grant; Animal-studies; Light-metals; Radiochemical-analysis; Acute-exposure; Biological-effects; Physiological-response; Medical-research; Histochemical-analysis; Excretion
Contact
Physiology University of Michigan 6811 Medical Science II Ann Arbor, Mich
CODEN
APLPE7
CAS No.
7440-66-6; 13982-39-3; 7646-85-7; 58-94-6; 52-90-4; 71-00-1
Publication Date
19811101
Document Type
Journal Article
Funding Amount
243305
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00913
Issue of Publication
5
ISSN
1040-0605
Priority Area
Other Occupational Concerns; Grants-other
Source Name
American Journal of Physiology: Lung Cellular and Molecular Physiology
State
MI
Performing Organization
University of Michigan at Ann Arbor, Ann Arbor, Michigan
TOP