Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Pulmonary function responses in cats following long-term exposure to diesel exhaust.

Authors
Moorman-WJ; Clark-JC; Pepelko-WE; Mattox-J
Source
J Appl Toxicol 1985 Oct; 5(5):301-305
NIOSHTIC No.
00136478
Abstract
Physiological effects of long term inhalation of diesel emissions were investigated in cat lungs. During the first 61 weeks of exposure, the exhaust was diluted to produce a particulate concentration of 6 milligrams per cubic meter (mg/m3). For the balance of exposure, it was adjusted to produce a concentration of 12mg/m3. The animals were exposed 8 hours per day, 7 days per week, for 2 years. Pulmonary mechanical properties were measured. Following the first 61 weeks of exposure, no significant patterns of response were found in mechanical properties, diffusing capacity, uniformity of distribution, or ventilatory performance. A clearly defined response existed at the end of 124 weeks of exposure. The reduction in inspiratory capacity, vital capacity, and total lung capacity with normal values for dynamic ventilatory function indicated a lesion that restricted breathing but did not cause airway obstruction. This restrictive disease was compatible with a diagnosis of pulmonary fibrosis of the interstitial or intraalveolar type. Additional support for the diagnosis was the finding of impaired diffusing capacity. The authors conclude that adverse pulmonary responses occur with high concentrations of diesel emission.
Keywords
NIOSH-Author; Pulmonary-disorders; Laboratory-animals; Respiration; Breathing-atmospheres; Toxic-effects; Exposure-limits; Pulmonary-function; Exposure-levels; Toxic-materials
CODEN
JJATDK
Publication Date
19851001
Document Type
Journal Article
Fiscal Year
1986
NTIS Accession No.
NTIS Price
Issue of Publication
5
NIOSH Division
DBBS
Source Name
Journal of Applied Toxicology
State
OH
TOP