A neuropathologic study of acrylamide intoxication.
Yeshiva University, New York New York 1978 Jan; :1-12
Both chronic and acute effects of acrylamide (79061) intoxication were studied in monkeys and rats. Adult rhesus-monkeys were given week for up to 78 weeks. One monkey received 3mg/kg 5 days a week for 49 weeks. Monkeys were weighed periodically. Pacinian corpuscles or sural nerves were biopsied at intervals. Animals were killed and central and peripheral nervous system tissues were sampled and prepared for light and electron microscopy. Results were compared with those from a control untreated group previously reported. Dying back patterns of nerve damage from acrylamide were studied in Sprague-Dawley-rats. Acrylamide was applied to exposed sciatic nerves in concentrations of 320, 180, and 160mg per milliliter for 45 minutes. After 5 days animals were killed and sciatic nerves were examined. Similar applications were made to nerves with iodoacetic-acid (64697). Chronically treated animals showed neither weight loss nor decreased gain compared with controls. A few Pacinian corpuscles were found at biopsy but no pathological changes were found in sural nerve biopsies. The animal receiving 3mg/kg displayed scattered axonal swelling in the medulla oblongata and the lumbar spinal cord. Nerves treated with acrylamide remained intact although nerve fibers treated with iodoacetic-acid degenerated completely. The author concludes that since acrylamide did not damage nerve fibers, it may act at another locus to produce damage seen in animals treated at higher concentrations. Possibly longer exposure would produce observable nerve damage. The mechanism of injury requires more study.
NIOSH-Grant; Poisons; Toxic-effects; Neurotoxicity; Medical-research; Medical-monitoring; Animal-studies; Amides
Final Grant Report
Yeshiva University, New York New York
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461