Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

In Vivo Effects Of Metals On Lung Peroxidation, Final Report.

Authors
NIOSH
Source
NIOSH :4 pages
Link
NIOSHTIC No.
00134975
Abstract
The in-vitro effects of metals on lung lipid peroxidation were examined. Guinea-pig or rat lung microsomes were incubated with iron (7439896), zinc (7440666), cadmium (7440439), nickel (7440020), cobalt (7440484), tin (7440315), manganese (7439965), or lead (7439921) and assayed for evidence of lipid peroxidation. Only iron caused lipid peroxidation. The lung microsomes were then incubated with each of the metals in combination with iron. Cadmium and zinc enhanced the iron induced lipid peroxidation. Cobalt, nickel, tin, and manganese inhibited iron induced lipid peroxidation. The other metals had no effect. Lung microsomes were assayed for glutathione, superoxide-dismutase, glutathione-peroxidase, ascorbate, and glutathione-reductase. All substances were found to be present in measurable quantities. Their protective abilities against lipid peroxidation were measured. Only ascorbate was found to protect the lungs against lipid peroxidation. The authors note that an active transport system for ascorbate exists in lung cells. This ensures the availability of ascorbate for its protective function. Results of in-vitro studies of metal combinations on lipid peroxidation are important since occupational exposures usually involve combinations of metals rather than individual metals.
Keywords
NIOSH-Author; Heavy-metals; Toxic-effects; Bioassays; Enzymatic-effects; Industrial-medicine; Occupational-medicine; Biological-effects; Cytotoxic-effects;
CAS No.
7439-89-6; 7440-66-6; 7440-43-9; 7440-02-0; 7440-48-4; 7440-31-5; 7439-96-5; 7439-92-1;
NTIS Accession No.
PB84-242031
NTIS Price
A01
Source Name
NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, 4 pages, 9 references
State
OH;
TOP