Occupational exposures and selected congenital defects, December 1, 1978 - January 31, 1980, final report.
Johns Hopkins University, Baltimore Maryland, 1981 Jan; :1-126
The incidence of congenital heart defects among children of mothers exposed to antinauseants and maternal and paternal exposure to lead (7439921) (Pb) before and during pregnancy was assessed. Cases of congenital malformations were identified in six counties of the metropolitan Baltimore, Maryland area for 1970 through 1976. Information on parental exposures before and during pregnancy was obtained by mailed questionnaires and telephone follow ups. Additional information was obtained from birth certificates and medical records. A total of 206,107 live births occurred in the six county area during the study period. Among these, 140 cases of congenital malformations occurred. The incidence rate per county ranged from 4.9 to 7.1. The incidence of cases in which the mother took antinauseants was 19.3 percent, versus 25.1 percent among comparisons, the general population. The incidence rate of these malformations among the offspring of parents who had Pb exposure was 6.0 and 37.6 percent for mothers and fathers, respectively. The corresponding incidence rates in the general population were 2.7 and 26.6 percent, respectively. The author concludes that paternal as well as maternal occupational exposure may be an important factor in the etiology of congenital heart defects and other malformations.
NIOSH-Grant; Occupational-exposure; Reproductive-effects; Pregnancy; Congenital-effects; Lead-absorption; Teratogens; Pharmaceuticals; Cardiovascular-system-disorders
Final Grant Report
NTIS Accession No.
Johns Hopkins University, Baltimore Maryland
Epidemiology John Hopkins School 615 N Wolfe Street Baltimore, MD 21205