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Occupational risks of pesticide exposure for females. Terminal progress report.

Authors
Swartz-WJ
Source
Louisiana State Univ Med Ctr, New Orleans Louisiana, 1982 Jan; :1-13
Link
NIOSHTIC No.
00134967
Abstract
The effects of pesticides on the female reproductive system were studied in chick embryos and mice. Carbaryl (63252) was administered to chick embryos in doses of 1.0 to 10.0 milligrams (mg) for 5 or 12 days. When exposed for 12 days, carbaryl became increasingly embryotoxic and abnormalities such as subcutaneous edema and defects in the hind limbs were observed. Female mice were given 50mg per kilogram (kg) DDT (50293) orally once a week for 4 weeks. They were then treated with gonadotropins. Exposed mice did not ovulate in response to the gonadotropins. In acute experiments, virgin female mice were administered 10 to 300mg/kg DDT daily for 5 days. They were then treated with exogenous gonadotropins and ovaries were examined. Only mice receiving 10 or 50mg/kg DDT survived the experiment. A significant reduction in the number of oocytes ovulated in response to the gonadotropins occurred. Mice were treated with malathion (121755) using the same protocol as with DDT. Malathion did not affect the number of eggs ovulated in response to gonadotropins. The author concludes that DDT has a significant effect on the female reproductive system.
Keywords
NIOSH-Grant; Animal-studies; Pesticides-and-agricultural-chemicals; Reproductive-hazards; Teratogens; Biological-effects; Toxicology; Comparative-toxicology; Medical-research
CAS No.
63-25-2; 50-29-3; 121-75-5
Publication Date
19820101
Document Type
Final Grant Report
Funding Amount
706204
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
PB84-241645
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00835
NIOSH Division
OEP
Source Name
Louisiana State Univ Med Ctr, New Orleans Louisiana
State
LA
Performing Organization
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
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