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Mesothelioma in relation to asbestos, terminal progress report.

Authors
Smith-WE
Source
NIOSH 1971 Jan; :1-21
Link
NIOSHTIC No.
00134964
Abstract
The carcinogenicity of asbestos (1332214) was examined in LVGLAK- hamsters. Hamsters were given a single injection of 0.5 milliliter of a suspension of 1 of 23 preparations of asbestos or other minerals into the right pleural cavity. Animals were followed for 650 to 700 days after injection or until death. Necropsies were performed. Thoracic contents were examined microscopically and histologically. Presence or absence of pleural adhesions and their character, plaques, thrombi, or other pathologies were noted. Mesotheliomas were found after injection of soft chrysotile (12001295), harsh chrysotile, amosite (12172735), diatomaceous earth, crocidolite (12001284), anthophyllite (16829439), nickel (7440020) powder, and microquartz fibers. Tumors appeared more quickly with harsh chrysotile than with the soft variety. Fibrogenic and carcinogenic responses to chrysotile, amosite, and crocidolite were reduced with reductions in dose. At a dose of 1 milligram, tumors were found only in response to crocidolite. Reduction of fiber length of chrysotile reduced fibrogenic responses and eliminated carcinogenic responses. Electron micrography showed phagocytosis of asbestos fibers by macrophages and by epithelial cells after chrysotile injection.
Keywords
NIOSH-Grant; Animal-studies; Dust-exposure; Toxic-effects; Laboratory-testing; Clinical-techniques; Testing-equipment; Carcinogens
CAS No.
1332-21-4; 12001-29-5; 12172-73-5; 12001-28-4; 16829-43-9; 7440-02-0
Publication Date
19710101
Document Type
Final Grant Report
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
PB84-241603
NTIS Price
A03
Identifying No.
Grant-Number-EC-00226-04
NIOSH Division
OEP
Source Name
NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio
State
OH; NJ
Performing Organization
Fairleigh Dickinson University
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