Neoplastic effect of vinyl chloride in mouse lung - lower doses and short-term exposure.
Mount Sinai School of Medicine, New York New York, 1982 Jan; :1-27
The neoplastic pulmonary effects of vinyl-chloride (75014) (VC) were studied in mice. Male CD1-mice were exposed to VC vapor at concentrations of 2500 or 6000 parts per million (ppm) for 5 to 6 months. Animals were then killed and studied for histopathological changes. CD1-mice were exposed to 0.1, 10, 100, 300, or 600ppm VC for 4 weeks and were observed for at least 41 weeks. Animals were killed at intervals up to 41 weeks after exposure and lungs were studied for histopathological changes. Ninety six percent of the mice exposed to 2500 or 600ppm VC developed pulmonary tumors. These tumors were alveologenic and were characterized by large irregularly shaped mitochondria, tight junctions between adjacent cells, and lack of mucinous secretory granules and cilia. In mice exposed to VC for 4 weeks, the tumor incidence was 5 percent at 1ppm, 16 percent at 10ppm, 37.5 percent at 100ppm, 68.4 percent at 300ppm, and 92 percent at 600ppm. Induction times of the tumors was also dose related, ranging from 10 weeks at 600ppm to 40 weeks at 1, 10, and 100ppm. The author concludes that alveologenic tumors arose as a result of a transformation of type II epithelium through a hyperplastic form.
NIOSH-Grant; Animal-studies; Respiratory-neoplasms; Dose-response; Biological-effects; Pathomorphology; Medical-research; Industrial-chemicals; Plastics
Final Grant Report
NTIS Accession No.
Mount Sinai School of Medicine, New York New York
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