Toxicity of inhaled mycotoxins.
NIOSH 1981 Jan:1-4
The toxicity of mycotoxins was studied in rats. Rats received intratracheal instillation of secalonic-acid-D (35287695) (SEC) in unspecified doses and were examined for histopathological changes. Rats were administered 0.25 milligram per kilogram T2 toxin (21259201). Sixteen hours later, animals were exposed to an aerosol of Serratia marcescens, and were killed immediately after exposure or 4 hours later. Lungs were assayed for Serratia marcescens. Rat alveolar macrophages were incubated with T2 toxin and diacetoxyscirpenol (2270408). The mixtures were assayed for viable alveolar macrophages. SEC was found to be toxic at lower doses than previously thought (doses not specified). Pathological changes were confined to the lungs and consisted of necrosis of the bronchial epithelium, focal areas of granulomatous inflammation, and hyperplasia of the epithelium. Animals administered T2 toxin cleared 45 percent of Serratia marcescens after 4 hours. Controls cleared 68 percent of the bacteria after 4 hours. T2 toxin and diacetoxyscirpenol reduced the viability of alveolar macrophages by as much as 50 percent.
NIOSH-Author; Animal-studies; Pathomorphology; Bioassays; Biological-effects; Medical-research; Exposure-limits; Health-standards; Toxic-effects
35287-69-5; 21259-20-1; 2270-40-8
NTIS Accession No.
NIOSH, U.S. Department of Health and Human Services, 4 pages, 3 references