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Special occupational hazard review. Alternatives to di-2-ethylhexyl phthalate ("DOP") respirator quantitative fit testing.

Authors
NIOSH
Source
NIOSH 1983 Mar; :1-31
NIOSHTIC No.
00134586
Abstract
The toxicity of dimethicone (9006659), di-2-ethylhexyl-sebacate (7313544) (DEHS), and corn-oil (8001307) is reviewed. The goal is to suggest alternatives to the use of di-2-ethylhexyl-phthalate (117817) (DEHP) in quantitative fit testing of respiratory protective devices. DEHP has been used for many years to generate a polydisperse aerosol test atmosphere in testing and to determine facial leakage in individual respirator wearers by quantifying aerosol leakage by light scattering photometry. However, DEHP has been found to be carcinogenic in two rodent species. NIOSH has thus reevaluated the overall toxicity of DEHP in respirator testing. Refined corn-oil, DEHS, and dimethicone exhibit polydisperse aerosol properties essentially equivalent to those of DEHP. Limited available reports indicate little toxicity data on DEHS and dimethicone that is relevant to testing. Refined corn-oil demonstrates lack of carcinogenic potential in its extensive use as a vehicle in carcinogenesis bioassay and in other more direct experimental applications. The author concludes that refined corn-oil aerosol is best suited as an alternative to DEHP in testing.
Keywords
NIOSH-Author; NIOSH-Criteria-Document; Fumes; Safety-research; Industrial-safety; Respiratory-gas-analysis; Pulmonary-function-tests; Carcinogens; Animal-studies; Aerosol-generators; Respiratory-protective-equipment
CAS No.
9006-65-9; 7313-54-4; 117-81-7
Publication Date
19830301
Document Type
Numbered Publication; Criteria Document
Fiscal Year
1983
NTIS Accession No.
PB83-250613
NTIS Price
A04
Identifying No.
(NIOSH) 83-109
Source Name
National Institute for Occupational Safety and Health
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