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Machine Oils And Nitrosamines Study For Carcinogenesis In Mice.

Authors
Mulligan-LT; Williams-S; Plankenhorn-LJ; Garner-FM
Source
NIOSH 1982 Sep:151 pages
Link
NIOSHTIC No.
00134512
Abstract
The effects of 11 synthetic machine cutting oils were examined in mice. Each oil was analyzed for diethanol-N-nitrosamine (1116547) by gas chromatography. Groups of Agouti-C3H/HEJ-mice received 0.05 milliliters of each oil topically twice weekly for 98 weeks. Each group consisted of 50 males and 50 females. During the treatment period, mice were observed for clinical symptoms. Gross and microscopic pathological studies were conducted at the end of the experiment. A high incidence of deaths were seen in mice given cutting oil number 4 which contained the highest measured concentration of diethanol-N-nitrosamine at 4.57 milligrams per gram. Treatment site masses were observed in all groups except controls. Nontreatment site tumors was seen in all females, located primarily in the mammary glands. Hepatocellular neoplasia was the only significant histological finding; it was seen most frequently in mice given cutting oil number 4 and cutting oil number 6. The incidence of proliferative liver lesions was higher in females than in males. The authors conclude that the materials in cutting oils 4 and 6 may be oncogenic to the liver. The authors also conclude that screening programs are necessary to measure methemoglobin concentrations in workers handling these oils.
Keywords
NIOSH-Contract; Machine-shop-workers; Animal-studies; Hepatotoxicity; Toxic-effects; Occupational-exposure; Employee-exposure; Pathogenicity; Medical-research; Contract-210-77-0136;
CAS No.
1116-54-7;
Publication Date
19820917
Funding Type
Contract;
Fiscal Year
1982
NTIS Accession No.
PB87-126355
NTIS Price
A09
Identifying No.
Contract-210-77-0136
NIOSH Division
DBBS;
Source Name
Division of Biomedical and Behavioral Sciences, NIOSH
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