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Elemental mercury polyneuropathy.

Authors
Albers-JW; Cavender-GD; Levine-SP; Langolf-GD
Source
University of Michigan at Ann Arbor, 1982 Jan; :1-28
Link
NIOSHTIC No.
00133330
Abstract
Peripheral neurotoxicity associated with exposure to inorganic mercury (7439976) vapors was investigated. Clinical neurological evaluations, nerve conduction evaluations, and medical questionnaires and interviews were conducted at three chloralkali factories (SIC-2812). Of the 138 workers examined, 77 had significant potential exposures to mercury. All subjects had been in a mercury control program wherein individuals with monthly spot sample urine mercury concentrations exceeding 50 milligrams per liter were removed from exposure. Of 138 workers, 18 had mild sensory disturbances that were evidenced by significantly reduced clinical distal vibratory and pin sensation, reduced distal strength, and reduced muscle stretch reflexes. Significant differences were also see in tests of vibration, touch, and two point discrimination. Affected subjects were older (average age of 43) and had an average of 13 years on the jobs, compared with an average age of 33 and 8 years on the job for normal subjects. Electrodiagnostic abnormalities were more frequent in subjects with polyneuropathy. Subjects with clinical evidence of polyneuropathy had higher mercury urine indexes. The authors conclude that elemental mercury exposure is associated with a clinically significant sensorimotor polyneuropathy. The degree of neurologic impairment is related to the magnitude of exposure.
Keywords
NIOSH-Grant; Fumes; Air-contamination; Exposure-levels; Poisons; Metal-poisoning; Brain-disorders; Muscular-disorders
CAS No.
7439-97-6
Publication Date
19820101
Document Type
Final Grant Report
Funding Amount
282722
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
PB84-239466
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00707
NIOSH Division
OEP
SIC Code
2812
Source Name
University of Michigan at Ann Arbor
State
MI
Performing Organization
University of Michigan at Ann Arbor
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