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Endocrine function of workers exposed to PBB aAnd PBBO. Terminal progress report.

Authors
Bialik-O
Source
University of Pennsylvania, Philadelphia, Pennsylvania, 1982 Mar; :1-63
Link
NIOSHTIC No.
00133186
Abstract
Thyroid and reproductive dysfunction was investigated in workers exposed for at least 240 hours to decabromobiphenyl (13654096) (PBB) and decabromobiphenyloxide (1163195) over a 4 year period. The average period of employment was 3.9; mean age, 34.7. Medical questionnaires, physical examinations, and laboratory tests were conducted. Air samples of PBB in the manufacturing area showed 0.18 to 0.23 milligrams per cubic meter for an 8 hour time weighted average. Of 18 workers exposed for 3 years or longer, thyroid nodules were seen in 3; another nodule was seen in a worker exposed to high chlorine (7782505) concentrations. Significant correlation was seen between length of employment and concentrations of follicle stimulating hormone (FSH) in workers exposed to PBB. An abnormal FSH value was found in only one worker. A testicular cyst was found in one exposed worker, and epididymal nodules in two others. No testicular or epididymal nodules were seen among comparisons. No detectable PBB was found in serum. The author concludes that thyroid hyperplasia may result from exposure to PBB, but no definite statement can be made concerning adverse effects on the prevalence of testicular and epididymal nodules because of their prevalence in the general population.
Keywords
NIOSH-Grant; Air-contamination; Air-quality-control; Fumes; Industrial-chemicals; Occupational-exposure; Industrial-hazards; Endocrine-system-disorders
CAS No.
13654-09-6; 1163-19-5; 7782-50-5
Publication Date
19820301
Document Type
Final Grant Report
Funding Amount
133675
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
PB84-238377
NTIS Price
A05
Identifying No.
Grant-Number-R01-OH-01034
NIOSH Division
OEP
Source Name
University of Pennsylvania Philadelphia Pennsylvania
State
PA
Performing Organization
Research Medicine University of Pennsylvania Medical Center Philadelphia, PA 19104
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