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Final progress report. Biochemical and physiological response to toxic stress.

Authors
Murphy-SD
Source
Harvard University, Boston, Massachusetts, 1980 May; :1-5
Link
NIOSHTIC No.
00133050
Abstract
Responses to toxic stress are reviewed. The following are examined: characterization of induced liver alkaline-phosphatase and other enzymes altered by toxic chemicals; the role of adrenal hormones and drugs on the toxicity and metabolism of halogenated hydrocarbons; the relationship of anticholinesterase action of organophosphates and increased adrenocortical activity; and the role of drugs, the environment and nutritional stress on neurological deficits produced by acrylamide (79061). Emphasis is placed on investigations of biochemical aspects of toxic stress induced by exposure to haloolefins, acrylamide, and metals. Toxic actions of 1,1- dichloroethylene (75354) (1,1-DCE), 2-chlorobutadiene (126998), 1,1- dibromoethylene (593920), vinyl-chloride-monomer (75014), acrylamide, copper (7440508), and mercury (7439976) are presented. The toxicity of 1,1-DCE is produced by hepatotoxic action in the absence of lipid peroxidation; a role for glutathione in the modulation of hepatotoxicity of 1,1-DCE is implicated. Inhalation tests in rats are cited for vinyl-chloride-monomer, in which hepatotoxicity does not occur; simultaneous inhalation of vinyl- chloride-monomer and 1,1-DCE at a ratio of 5:1 prevents the acute hepatotoxic effects of 1,1-DCE. A quantifiable method for measuring the functional neuromuscular deficit produced in rats by acrylamide is described. The method uses the rotorod principle and can assay the onset and duration of functional neuropathy in relation to sciatic nerve beta-glucuronidase.
Keywords
NIOSH-Grant; Biochemical-analysis; Physiological-measurements; Animal-studies; Poisons; Safety-research; Medical-research; Medical-monitoring
CAS No.
79-06-1; 75-35-4; 126-99-8; 593-92-0; 75-01-4; 7440-50-8; 7439-97-6
Publication Date
19800512
Document Type
Final Grant Report
Funding Amount
274679
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
PB84-240092
NTIS Price
A01
Identifying No.
Grant-Number-R01-OH-00315
NIOSH Division
OEP
Source Name
Harvard University
State
MA
Performing Organization
Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
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