Terminal progress report. Skin effects of chemical exposure in rubber workers.
University of North Carolina, Chapel Hill, 1982 Jan; :1-115
An epidemiologic study was conducted to investigate the incidence of skin cancer in the rubber and tire manufacturing industry (SIC-3069, SIC-3011). The association between squamous cell carcinoma and seven raw materials used in the industry was evaluated. All subjects were part of a retrospective cohort from two companies. Cases were obtained from tumor registries of hospitals and matched comparisons were selected from the cohort. A total of 86 skin cancer cases were identified; 31 from Company 1, and 55 from Company 2. More than 70 percent of the tumors from each company were squamous cell carcinomas. About 75 percent of workers from both companies were hired before 1930. Data for Company 1 supported a positive association between length of employment and squamous cell carcinoma. Squamous cell cases were employed for 5.2 years longer than comparisons. For Company 2, cases had shorter durations of employment than comparisons and employment duration was 2.3 years less for squamous cell cases. Materials positively associated with skin cancer in Company 1 were rubber stock, solvents, and lubricating oils. No strong associations with skin cancer were seen for any materials in Company 2.
NIOSH-Grant; Industrial-chemicals; Toxic-effects; Rubber-manufacturing-industry; Occupational-exposure; Employee-exposure; Safety-research; Skin-absorption
Final Grant Report
NTIS Accession No.
University of North Carolina
Epidemiology University of North Carolina Occupational Hlth Studies Grp Chapel Hill, N C 27514