Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Immunology of Grain and Other Organic Dusts.

Authors
Olenchock-SA
Source
NIOSH 1982:15 pages
Link
NIOSHTIC No.
00132132
Abstract
The interactions between organic dusts and the human and animal complement systems are reviewed, and gram negative bacterial endotoxins are discussed. A comprehensive series of experiments with grain dust, Aspergillus, and cotton dust samples are reported. These experiments were designed to study the mechanisms involved in nonspecific activation of immunologic events which result in inflammation. It is noted that grain dust consists of a heterogenous mixture of materials which have not been adequately characterized. The role of Aspergillus-flavus in producing toxic, mutagenic, carcinogenic, and teratogenic responses is considered. The complement dependent respiratory impairment in an animal model of acute allergic lung disease using Aspergillus as an inhalant antigen is explored. Experiments monitoring the acute pulmonary responses to cardroom cotton dust in experimental animals are cited. Preliminary investigations of endotoxins in animal confinement units which showed that settled and airborne dusts from swine and poultry houses contain large amounts of gram negative bacterial endotoxins are noted. The author concludes that those involved in farming, grain handling, animal rearing, textile manufacturing, and sewage treatment are at risk to dust and contaminant exposures.
Keywords
NIOSH-Author; Dust-exposure; Allergic-reactions; Airborne-particles; Lung-disorders; Pulmonary-function; Toxic-effects; Sampling-methods; Laboratory-testing;
Publication Date
19820101
Fiscal Year
1982
NTIS Accession No.
PB83-232041
NTIS Price
A03
Source Name
NIOSH, U.S. Department of Health and Human Services, Morgantown, West Virginia, NTIS PB83-232-041, 15 pages, 23 references
State
VA; WV;
TOP