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Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers.

Authors
Lloyd-JW
Source
J Occup Med 1975 May; 17(5):333-334
NIOSHTIC No.
00130890
Abstract
Cases of angiosarcoma of the liver in vinyl-chloride (75014) and polyvinyl-chloride (9002862) workers are reviewed. In January, 1974, three cases of angiosarcoma of the liver were reported among employees of a single vinyl-chloride polymerization facility. Subsequently 29 additional cases were recognized from the United States and nine other nations. All but three were diagnosed within the 7 years preceding 1975. An exact estimate of the incidence of angiosarcoma of the liver among polymerization workers cannot be determined but it is apparent that these workers are at high risk. About 5,600 workers are currently employed at 36 facilities in the United States. All the facilities from which angiosarcoma of the liver have been reported have been in operation more than 25 years. So far, 15 cases of liver angiosarcoma have been reported in the United States. Nine cases have been found in a facility employing fewer than 300 workers. The average latent period from first exposure to diagnosis is about 19 years. Consequently, most cases are appearing in the older facilities. It appears that these workers are also at high risk for other malignant neoplasms. Cases of angiosarcoma have been reported in other workers with exposure to vinyl-chloride. The relative youth of these workers in comparison with workers in the general population with liver cancer suggests a common etiology although the cause and effect relationship to vinyl- chloride exposure cannot be established. The author concludes that polymerization workers may not be the only industrial population at risk from exposure to vinyl-chloride or polyvinyl-chloride.
Keywords
JOCMA7; NIOSH-Author; Industrial-environment; Occupational-exposure; Chemical-analysis; Analytical-models; Exposure-levels; Physiological-measurements; Quantitative-analysis; Hygiene; Workplace-studies
CODEN
JOCMA7
CAS No.
75-01-4; 9002-86-2
Publication Date
19750501
Document Type
Journal Article
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0096-1736
Source Name
Journal of Occupational Medicine
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