Histopathologic data on Golden-Syrian-hamsters and Fischer-344-rats dosed with Yellow-3 (1342296) (Y3) dye was compiled. Animals were given 0.56 to 3.16 milligrams per 0.2 milliliters Y3 intratracheally in saline solution once a week for 15 weeks, and fed Y3 at 0.8 percent in the diet for 27 months. The organs in the animals of both sexes that were examined were: skin, mammary glands, muscles, salivary glands, mandibular lymph nodes, sciatic nerves, thymus, larynx, thyroid, parathyroid, trachea, bronchus, esophagus, adrenals, stomach, duodenum, jejunum, ileum, cecum, colon, rectum, mesenteric lymph nodes, lungs, liver, gall bladder, spleen, pancreas, kidneys, heart, urinary bladder, cerebellum, cerebrum, pituitary gland, femur, bone marrow, and nasal cavity. Ovaries and uteri were studied in females, and seminal vesicles, prostate gland and testes were studied in males. Data showed that Y3 was oncogenic in the adrenal cortex of male hamsters, and in the pancreas of male rats when administered intratracheally. Y3 given in the diet was oncogenic in the adrenal glands of both sexes of hamsters, in the liver and urinary tracts of male rats, and in the endocrine system of female rats.