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Report on Women Pharmaceutical Workers and Adverse Reproductive Outcomes.

Authors
Leffingwell-SS; Robinson-C; Lee-ST; Ditzel-C; Hornung-R; Cottrill-C; Stepehnson-F; Halperin-W
Source
NIOSH 1983 Jun:28 pages
Link
NIOSHTIC No.
00130220
Abstract
A reproductive history survey of past and current female employees of pharmaceutical laboratories (SIC-2934) was conducted using a retrospective cohort study design. A total of 191 laboratory workers and 318 comparisons participated in telephone interviews. A panel of physicians classified responses into categories of congenital malformation, perinatal illness, normal physiologic variant, and normal. Age and parity groups were used as strata when making comparisons on reproductive outcome between laboratory and administrative workers. Women who had previously worked in the laboratory reported significantly greater proportions of malformations during the early 1970s than did comparisons. Specifically, the proportion of infants born with malformations to mothers who worked in the laboratory at the estimated date of conception was significantly different from the proportion of comparisons. The proportion of miscarriages, and differences in birth weight were not significantly different. The authors conclude that there was a significantly higher proportion of congenital malformations among children born to women employed in the laboratory area of a pharmaceutical research facility. The cluster was limited in time and results may have been biased by social and economic traits. In addition, the study was not a randomly selected population, but rather a self reported cluster of miscarriages and stillbirths.
Keywords
NIOSH-Author; Laboratory-workers; Risk-analysis; Risk-factors; Epidemiology; Teratogenesis; Birth; Occupational-exposure;
Publication Date
19830601
Fiscal Year
1983
NTIS Accession No.
PB84-148956
NTIS Price
A03
SIC Code
2934;
Source Name
NIOSH, Public Health Service, U.S. Department of Health and Human Services, 28 pages, 11 references
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