Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Summarization Of Recent Literature Pertaining To An Occupational Health Standard For 1,1,1-Trichloroethane.

Authors
Anonymous
Source
NIOSH 1980 Jun:40 pages
Link
NIOSHTIC No.
00129477
Abstract
Recent literature on occupational health standards for 1,1,1- trichloroethane (71556) (TCE) is reviewed. Human effects to TCE exposure are discussed. Systemic absorption of TCE occurs following skin contact. TCE or its principal metabolite trichloroethanol (115208) have been detected in blood, urine, or expired air after dermal exposure. It is not clear whether chronic exposure to TCE at low concentrations causes the same adverse neurological and behavioral effects seen with exposure to other chlorinated solvents. Experimental animal studies are discussed. TCE is poorly metabolized and tends to accumulate in body fat of rats under chronic exposure conditions. TCE has been found to cause cardiac depression in various animal species. Mutagenicity and carcinogenicity studies are considered. It is noted that in-vitro studies have given conflicting results concerning the carcinogenic potential of TCE. Positive results with TCE in a mammalian cell transformation assay conflict with negative results in the Ames Salmonella assay. Work practices and engineering controls are discussed. Sampling and analytical procedures are considered. The authors emphasized that additional studies are necessary to determine if TCE poses a cancer threat.
Keywords
NIOSH-Contract; Safety-research; Health-protection; Skin-absorption; Industrial-chemicals; Mutagenicity; Biological-effects; Health-hazards; Contract-210-78-0009;
CAS No.
71-55-6; 115-20-8;
Publication Date
19800601
Funding Type
Contract;
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Identifying No.
Contract-210-78-0009
Source Name
NIOSH, Public Health Service, U.S. Department of Health, Education, and Welfare, Rockville, Maryland
State
MD;
TOP