Summarization Of Recent Literature Pertaining To An Occupational Health Standard For 1,1,1-Trichloroethane.
NIOSH 1980 Jun:40 pages
Recent literature on occupational health standards for 1,1,1- trichloroethane (71556) (TCE) is reviewed. Human effects to TCE exposure are discussed. Systemic absorption of TCE occurs following skin contact. TCE or its principal metabolite trichloroethanol (115208) have been detected in blood, urine, or expired air after dermal exposure. It is not clear whether chronic exposure to TCE at low concentrations causes the same adverse neurological and behavioral effects seen with exposure to other chlorinated solvents. Experimental animal studies are discussed. TCE is poorly metabolized and tends to accumulate in body fat of rats under chronic exposure conditions. TCE has been found to cause cardiac depression in various animal species. Mutagenicity and carcinogenicity studies are considered. It is noted that in-vitro studies have given conflicting results concerning the carcinogenic potential of TCE. Positive results with TCE in a mammalian cell transformation assay conflict with negative results in the Ames Salmonella assay. Work practices and engineering controls are discussed. Sampling and analytical procedures are considered. The authors emphasized that additional studies are necessary to determine if TCE poses a cancer threat.
NIOSH-Contract; Safety-research; Health-protection; Skin-absorption; Industrial-chemicals; Mutagenicity; Biological-effects; Health-hazards; Contract-210-78-0009;
NIOSH, Public Health Service, U.S. Department of Health, Education, and Welfare, Rockville, Maryland