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The biological action of the coumarins.

Authors
Scheel-LD
Source
Microb Toxins 1972; 8:47-66
Link
NIOSHTIC No.
00128089
Abstract
The biologic activity of coumarin (91645) compounds is discussed. Uses of these substances in food, perfumes, and cosmetics is reviewed, and data on metabolic pathways is summarized. The results of numerous investigations on the toxic effects of coumarin, hydroxycoumarins, 4-hydroxycoumarin (1076386), and psoralens are discussed, along with studies of the formation and concentration of these compounds in mold and plant tissues. Biochemical and metabolic theories of coumarin formation in molds are evaluated. The author suggests that a symbiotic relationship exists between plant tissue and coumarin producing molds. These compounds appear to have a great potential for beneficial use; however, a better understanding of their mechanisms of action is needed.
Keywords
NIOSH-Author; Chemical-kinetics; Biological-effects; Biochemical-analysis; Metabolic-study; Pharmacodynamics; Food-additives; Chemical-properties; Cosmetics
CODEN
22HAAD
CAS No.
91-64-5; 1076-38-6
Publication Date
19720101
Document Type
Book or book chapter
Fiscal Year
1972
NTIS Accession No.
NTIS Price
ISBN No.
0120465027
Source Name
Microbial Toxins
State
NY
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