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Disodium tetrachloropalladate (Na2PdCl4), an inhibitor of rat liver mitochondrial electron transport.

Authors
Biagini-RE; Moorman-WJ; Winston-GW
Source
Toxicol Lett 1982 Jul; 12(2-3):165-170
NIOSHTIC No.
00126864
Abstract
The interaction of disodium-tetrachloropalladate (13820536) (Na2PdCl4) with isolated electron transport and energy metabolism was studied in Sprague-Dawley-rats. Adenosine-triphosphatase (ATPase) activity was assayed by the determination of proton ejection following addition of carbonyl-cyanide-m- chlorophenylhydrazine (555602) (CCCP) or Na2PdCl4. Phosphate were performed after the addition of 400 nanomoles of adenosine- stimulate proton ejection. At the highest concentrations, 64 micromolar, state 3 respiration rates with both succinate and mixture of 5 millimolar (mM) glutamate, 1mM malate, 1mM malonate were inhibited about twenty and forty percent of control values, respectively. Na2PdCl4 demonstrated no ability to stimulate state 4 respiration of ATPase. Along with an inhibition of the electron transport chain, Na2PdCl4 suppressed the rate of accumulation of protons during ADP phosphorylation. The authors conclude that Na2PdCl4 is a relatively potent inhibitor of mitochondrial electron transport and there is a multiphasic inhibitor interaction with the rat liver mitrochondrial electron transport system which yields primary inhibitors of respiration without observable interaction with the coupling system mechanics.
Keywords
NIOSH-Author; Analytical-methods; Analytical-chemistry; Bioassays; Laboratory-techniques; Chemical-analysis; Analytical-instruments
CODEN
TOLED5
CAS No.
13820-53-6; 555-60-2
Publication Date
19820701
Document Type
Journal Article
Fiscal Year
1982
NTIS Accession No.
NTIS Price
Issue of Publication
2-3
ISSN
0378-4274
NIOSH Division
DBBS
Source Name
Toxicology Letters
State
OH; NY
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