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Hairless mice as models for chloracne: a study of cutaneous changes induced by topical application of established chloracnegens.

Authors
Puhvel-SM; Sakamoto-M; Ertl-DC; Reisner-RM
Source
Toxicol Appl Pharmacol 1982 Jul; 64(3):492-503
NIOSHTIC No.
00126680
Abstract
Cutaneous changes induced by topical application of established chloracnegens were studied in female SKh:HR-1-hairless-mice and HRS/J-hairless-mice. Solutions of 0.1 milliliter of polychlorinated naphthalenes, polychlorinated biphenyls and 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) were dissolved in acetone and applied to the dorsal skin of the mice for a treatment period ranging from 2 to 10 weeks. The cutaneous changes were monitored during this time with punch biopsies of treated skin taken for histologic studies at regular intervals. Mice were killed at the end of the treatment. Most chloracnegens caused a pattern of cutaneous pathology without associated hyperkeratinization of the sebaceous follicles. Only 3,4,3',4' tetrachlorobiphenyl induced a true chloracne like syndrome. This syndrome caused massive hyperkeratosis of the sebaceous follicles and hyperkeratinization of intradermal pilar cysts further compounded by gross weight gain.
Keywords
NIOSH-Publication; NIOSH-Grant; Analytical-methods; Analytical-chemistry; Laboratory-techniques; Chemical-analysis; Histochemical-analysis; Biochemical-tests; Laboratory-animals
Contact
Medicine University of California 405 Hilgard Avenue Los Angeles, Calif 90024
CODEN
TXAPA9
CAS No.
1746-01-6
Publication Date
19820701
Document Type
Journal Article
Funding Amount
186835
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-01108
Issue of Publication
3
ISSN
0041-008X
Source Name
Toxicology and Applied Pharmacology
State
CA
Performing Organization
University of California Los Angeles, Los Angeles, California
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