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The acute oral toxicity of isomeric monobutylamines in the adult male and female rat.

Authors
Cheever-KL; Richards-DE; Plotnick-HB
Source
Toxicol Appl Pharmacol 1982 Mar; 63(1):150-152
NIOSHTIC No.
00125156
Abstract
The acute oral toxicity of isomeric-monobutylamines was investigated in Sprague-Dawley-rats. Male and female rats were administered 100, 200, 300, 400, 500 or 600 milligrams per kilogram (mg/kg) body weight of n-butylamine (109739), isobutylamine (78819), and sec- butylamine (13952846) and doses of 30, 40, 50, 70, 100 or 200 mg/kg tert-butylamine (75649) by gavage. Animals were observed for toxic reactions or mortality for 14 days. At death, animals were subjected to gross pathologic examination. Signs of toxicity observed included sedation, ataxia, nasal discharge, gasping and salivation, followed by convulsions and death at high doses. Pulmonary edema was noted on gross pathological examination. Tert- butylamine was the most toxic followed by sec-butylamine and isobutylamine with n-butylamine being the least toxic. The authors conclude there was a four fold difference in lethal dose for 50 percent of animals between the most and least toxic compounds tested, and there were no sex related differences in the toxicity of the monobutylamines.
Keywords
NIOSH-Author; Comparative-toxicology; Mortality-rates; Dose-response; Acute-toxicity; Pulmonary-system-disorders; Laboratory-animals; Invivo-study
CODEN
TXAPA9
CAS No.
109-73-9; 78-81-9; 13952-84-6; 75-64-9
Publication Date
19820330
Document Type
Journal Article
Fiscal Year
1982
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0041-008X
NIOSH Division
DBBS
Priority Area
Pulmonary-system-disorders
Source Name
Toxicology and Applied Pharmacology
State
OH
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