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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report, 3-Chloropropene.

Authors
McGregor-DB
Source
NIOSH 1981 Jul:191 pages
Link
NIOSHTIC No.
00123529
Abstract
Allyl-chloride (107051) (AC) was subjected to a tier II mutagenic test screening program. The assays included unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations of up to 9900 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposure to atmospheres containing 1 part per million (ppm) or 25ppm AC for 7 hours per day for 5 days; sperm abnormality test in male mice using the same conditions; cytogenetic tests in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; and sex linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 150ppm for 7 hours. There was no increase in UDS in cells treated with AC nor were there increases in the frequencies of cells with aberrations seen as a result of examination of bone marrow metaphase cell analysis. There were not effects of AC in the dominant lethal test on pregnancy, numbers of corpora lutea graviditatis or implantations, or the frequency of early deaths. Sperm abnormality frequency was not affected by treatment and sex linked recessive lethal mutation frequency was not increased. The author concludes that AC was devoid of genetic effects.
Keywords
NIOSH-Contract; Contract-210-78-0026; Mutagenesis; Toxicology; Bioassays; Screening-methods; Genetic-disorders;
CAS No.
107-05-1;
Publication Date
19810701
Funding Type
Contract;
Fiscal Year
1981
NTIS Accession No.
PB86-239845
NTIS Price
A10
Identifying No.
Contract-210-78-0026
Source Name
Inveresk Research International Limited, Musselburgh, Scotland, NIOSH, Cincinnati, Ohio, No. 39, 191 pages, 20 references
State
OH;
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