Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report, Methyl Bromide.

Authors
McGregor-DB
Source
NIOSH 1981 May:181 pages
Link
NIOSHTIC No.
00123526
Abstract
Methyl-bromide (74839) was subjected to a tier II mutagenic test screening program. Screening included the following assays: unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours and concentrations up to 70 percent in air; dominant lethal test in male rats and sperm abnormality tests in male mice with exposure to atmospheres containing 20 to 70 parts per million (ppm) methyl-bromide; cytogenetic test in male and female rats with bone marrow cells; and sex linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 20 or 70ppm for 5 hours. There was no increase in UDS in cells treated with methyl-bromide nor was the frequency of aberrant cells increased. There were no effects attributable to methyl-bromide in the dominant lethal test on pregnancy frequency, numbers of corpora lutea graviditatis or implantations, or the frequency of early deaths. Sperm abnormality frequency was not affected and sex linked recessive lethal mutation frequency was not increased as a result of methyl-bromide exposure. The author concludes that methyl-bromide was devoid of genetic effects.
Keywords
NIOSH-Contract; Contract-210-78-0026; Bioassays; Biochemical-tests; Toxicology; Genetic-disorders; Mutagenesis;
CAS No.
74-83-9;
Publication Date
19810530
Funding Type
Contract;
Fiscal Year
1981
NTIS Accession No.
PB83-130211
NTIS Price
A10
Identifying No.
Contract-210-78-0026
Source Name
Inveresk Research International Limited, Musselburgh, Scotland, NIOSH, Cincinnati, Ohio, No. 32, 181 pages, 17 references
State
OH;
TOP