Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report, Styrene Oxide.

Authors
McGregor-DB
Source
NIOSH 1981 Feb:172 pages
Link
NIOSHTIC No.
00123525
Abstract
Styrene-oxide (96093) (SO) was subjected to a tier II mutagenic test screening program. The screening included the following assays: unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations up to 50 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposure to atmospheres containing 15 or 100 parts per million (ppm) SO styrene-oxide for 7 hours per day for 5 consecutive days; sperm abnormality test in male mice using the same conditions; cytogenetic test in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; and sex linked recessive lethal test in Drosophila- melanogaster with exposure of 100ppm for 150 minutes. There was no increase in UDS in cells treated with SO and the frequencies of chromosomal aberrations were not increased in the rat bone marrow cells. There was a small effect attributable to SO in the dominant lethal test on pregnancy frequency and on the total number of implantations. Sperm abnormality frequency was slightly increased in mice dosed with 100 parts per million SO, while sex linked recessive lethal mutation frequency was not increased. The author concludes that SO did not show genetic effects detectable in the experiments apart from the small increase in the frequency of sperm with abnormalities.
Keywords
NIOSH-Contract; Contract-210-78-0026; Genetic-disorders; Mutagenesis; Toxicology; Polymers; Bioassays; Screening-methods;
CAS No.
96-09-3;
Publication Date
19810220
Funding Type
Contract;
Fiscal Year
1981
NTIS Accession No.
PB83-130203
NTIS Price
A09
Identifying No.
Contract-210-78-0026
Source Name
Inveresk Research International Limited, Musselburgh, Scotland, NIOSH, Cincinnati, Ohio, No. 29, 172 pages, 28 references
State
OH;
TOP