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Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable levels of exposure in man.

Authors
Alarie-Y
Source
Food Cosmet Toxicol 1981 Jan; 19(5):623-626
NIOSHTIC No.
00123273
Abstract
The median effective doses for respiratory inhibition (RD50) of 26 chemicals are reviewed and evaluated for establishing threshold limit values (TLV) in the workplace. The method of measuring the RD50 is described. RD50s and TLV time weighted averages (TWA) are listed for 26 chemicals including benzoquinone (106514) and styrene (100425), for which values had not previously been unpublished. Log graphs of TLV TWA were compared to 0.03 times the RD50 data. The author concludes that 0.03 RD50 is a useful predictor of sensory irritants that affect man, but does not predict metabolic activation or lung irritation.
Keywords
NIOSH-Publication; NIOSH-Grant; Exposure-limits; Respiratory-irritants; Toxicology; Pulmonary-system-disorders; Bioassays; Air-contamination; Standards
Contact
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
CODEN
FCTXAV
CAS No.
106-51-4; 100-42-5
Publication Date
19810101
Document Type
Journal Article
Funding Amount
332059
Funding Type
Grant
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00367
Issue of Publication
5
ISSN
0015-6264
Priority Area
Pulmonary-system-disorders
Source Name
Food and Cosmetics Toxicology
State
PA
Performing Organization
University of Pittsburgh, Pittsburgh, Pennsylvania
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