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Volcanic ash: toxicity to isolated lung cells.

Authors
Castranova-V; Bowman-L; Shreve-J; Jones-GS; Miles-PR
Source
J Toxicol Environ Health 1982 Jan; 9(2):317-325
NIOSHTIC No.
00122538
Abstract
The effects of inspiration of volcanic dust on respiratory function were studied in rat and rabbit lung cells and intact rats. Isolated lung cells were exposed to 1.5 or 5.0 milligrams per milliliter of volcanic ash and oxygen consumption, lipid peroxidation, cell membrane integrity, and superoxide anion release were determined with or without the addition of zymosan (9010724) particles. Intact rats received an intratracheal injection of a solution containing 9 milligrams ash and were killed 2 weeks later. Alveolar macrophages were isolated for oxygen consumption and superoxide secretion determinations. In-vitro exposure had little effect on oxygen consumption of rabbit type 11 cells, the oxygen consumption or superoxide release of resting alveolar macrophages, or the membrane integrity of rat alveolar macrophages. Volcanic ash caused no significant lipid peroxidation in rat lung microsomes. Superoxide anion release from zymosan to stimulated rat alveolar macrophages was inhibited after both in-vitro and in-vivo exposures. The authors conclude that inhibition of superoxide release by volcanic ash may interfere with alveolar macrophages to protect the lung from some types of respiratory infections and that workers exposed to high levels of volcanic ash may be subject to adverse respiratory function.
Keywords
JTEHDL; NIOSH-Author; Combustion-products; Mineral-dusts; Dust-inhalation; Laboratory-animals; Pulmonary-function; Toxicology; Lung-disorders; Cytotoxicity
CODEN
JTEHD6
CAS No.
9010-72-4
Publication Date
19820101
Document Type
Journal Article
Fiscal Year
1982
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0098-4108
Source Name
Journal of Toxicology and Environmental Health
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