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Diverse profiles of immunoreactivity in toluene diisocyanate (TDI) asthma.

Authors
Gallagher-JS; Tse-CS; Brooks-SM; Bernstein-IL
Source
J Occup Med 1981 Sep; 23(9):610-616
NIOSHTIC No.
00122371
Abstract
Immunoreactivity to mono and diisocyanate protein conjugates was evaluated in fifteen workers with toluene-diisocyanate (584849) (TDI) asthma and seventeen nonexposed volunteers. Intracutaneous skin tests, measurement of specific immunoglobulin to E by leucocyte inhibitory factor (LIF) tests were conducted using conjugates of human serum albumin and TDI (HSA-TDI) or hexamethylene-diisocyanate (822060) (HSA-HDI). Peripheral leucocytes of nine symptomatic workers produced LIF after exposure to HSA-TDI and four of these workers also exhibited LIF activity to HSA-HDI. No LIF activity was detected in nonexposed subjects or in a previously symptomatic worker removed from TDI exposure 7 years prior to testing.
Keywords
JOCMA7; NIOSH-Publication; NIOSH-Grant; Organic-solvents; Immunology; Occupational-medicine; Hematology; Immune-reaction; Immunological-tests; Blood-cells
Contact
Internal Medicine University of Cincinnati 231 Bethesda Avenue Cincinnati, Ohio 45267
CODEN
JOCMA7
CAS No.
584-84-9; 822-06-0
Publication Date
19810901
Document Type
Journal Article
Funding Amount
301375.00
Funding Type
Grant
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00773
Issue of Publication
9
ISSN
0096-1736
Source Name
Journal of Occupational Medicine
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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