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Tier II Mutagenic Screening of 13 NIOSH Priority Compounds, Individual Compound Report N-Methyl Dicyclohexylamine.

Authors
McGregor-D
Source
NIOSH 1981 Jun:203 pages
Link
NIOSHTIC No.
00122312
Abstract
The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
Keywords
NIOSH-Contract; Contract-210-78-0026; Bioassays; Screening-methods; Medical-screening; Mutagenesis; Analytical-methods;
CAS No.
7560-83-0;
Publication Date
19810622
Funding Type
Contract;
Fiscal Year
1981
NTIS Accession No.
PB83-126607
NTIS Price
A11
Identifying No.
Contract-210-78-0026
Source Name
Inveresk Research International Limited, Musselburgh EH21 7UB, Scotland, NIOSH, Cincinnati, Ohio, No. 36, 203 pages, 10 references
State
OH;
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