Multiple short-term effects of lead on the renin-angiotensin system.
Goldman-JM; Vander-AJ; Mouw-DR; Keiser-J; Nicholls-MG
J Lab Clin Med 1981 Feb; 97(2):251-263
The effects of lead (7439921) on the relationship between plasma renin and angiotensin II were studied. Male dogs were catheterized to measure hepatic renal flow and plasma renin activity. The effects of lead, 0.5 milligrams per minute, administered by continuous infusion for 3 hours, on these parameters and on arterial angiotensin II were measured. In some animals the effect of lead on the hepatic removal of renin was monitored by sampling hepatic portal blood. Plasma renin activity rose significantly over the 3 hour period of lead exposure. Although there was a linear relationship between angiotensin II levels and plasma renin activity following nonlead stimuli, this relation was changed with lead lowered angiotensin II levels. Hepatic removal of renin was shut off after 2 to 3 hours of lead administration. The authors conclude that the major cause of increased plasma renin activity after lead administration is the cessation of hepatic removal of renin and lead prevents angiotensin II levels from rising proportionately with plasma renin activity.
NIOSH-Publication; NIOSH-Grant; Heavy-metals; Hematology; Animal-studies; Toxicology; Immunology; Kidney-function; Lead-poisoning; Blood-plasma
Physiology University of Michigan 6811 Medical Science II Ann Arbor, Mich
Other Occupational Concerns; Grants-other
The Journal of Laboratory and Clinical Medicine
University of Michigan at Ann Arbor, Ann Arbor, Michigan