Electron microscopic observations of hepatic and subcutaneous hemangiosarcomas induced in mice exposed to vinyl chloride monomer.
Am J Ind Med 1981; 2(2):103-117
The ultrastructural characteristics of tumors induced in mice by vinyl-chloride (75014) were studied. Male mice were exposed by inhalation to 0 to 600 parts per million vinyl-chloride for 4 weeks. Animals were killed 0 to 65 weeks after exposure, and tissues were examined by electron microscope. Hemangiosarcomas and, more frequently, alveologenic tumors were induced. There was no ultrastructural difference between hemangiosarcomas induced by vinyl- chloride and those not related to exposure to this chemical. Although a clear dose dependence was not seen in hemangiosarcoma induction, the induction of alveologenic tumors was clearly dose related. The author concludes that in the mouse the alveolar epithelium is more sensitive than the capillary endothelium to the carcinogenicity of vinyl-chloride.
NIOSH-Publication; NIOSH-Grant; Laboratory-animals; Tumorigenesis; Ultrastructure; Carcinogenesis; Chlorinated-ethylenes; Vinyl-plastics; Dose-response
Community Medicine Mount Sinai School of Med Fifth Avenue & 100Th Street New York, N Y 10029
American Journal of Industrial Medicine
Mount Sinai School of Medicine, New York, New York