Neurobehavioral effects of methyl n-butyl ketone and methyl n-amyl ketone in rats and monkeys: a summary of NIOSH investigations.
Johnson-BL; Anger-W; Setzer-JV; Lynch-DW; Lewis-TR
J Environ Pathol Toxicol 1979 May/Jun; 2(5):113-133
The neurophysiological and behavioral effects in monkeys and rats of methyl-n-butyl-ketone (591786) (MBK) and methyl-n-amyl-ketone (110430) (MAK) were studied. Male albino Sprague-Dawley-rats and male Macaca-fascicularis-monkeys inhaled MBK and MAK at concentrations of 0, 100, or 1,000 parts per million (ppm) for hours per day, 5 days per week for up to 10 months. While exposure to 1,000 ppm MAK for 9 months was nontoxic, exposure to 1,000 ppm MBK
NIOSH-Author; Organic-solvents; Comparative-toxicology; Laboratory-animals; Behavioral-tests; Exposure-limits; Nervous-system-disorders
decreased motor nerve conduction
Journal of Environmental Pathology and Toxicology. Toxicological and Carcinogenic Health Hazards in the Workplace: proceedings of the First Annual NIOSH Scientific Symposium, Cincinnati, Ohio, April 1978