Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Human Responses to Controlled Exposures of Methylene Chloride Vapor.

Authors
Stewart-RD; Forster-HV; Hake-CL; Lebrun-AJ; Peterson-JE
Source
NIOSH 1973 Dec:82 pages
Link
NIOSHTIC No.
00120691
Abstract
The behavioral and health effects of exposure to methylene-chloride (75092) (CH2Cl2) vapor were studied. Eleven male subjects were exposed to 500 parts per million (ppm) of CH2Cl2 for 7.5 hours per day for 2 days or to concentrations of up to 250ppm for 5 days. Subjects were given a comprehensive medical examination prior to and following exposure. Blood counts and urinalyses were conducted. Alveolar breath samples were taken at various intervals. No deleterious health or behavioral effects were seen at any exposure dose. Carboxyhemoglobin (CoHb) concentrations were consistently increased and averaged over 5 percent at CH2Cl2 exposures of 250ppm for 7.5 hours. The authors conclude that exposure to methylene- chloride increases CoHb concentrations. They note that this measurement is not a good indicator of CH2Cl2 exposure because of the unknown presence of carbon-monoxide in industrial environments.
Keywords
NIOSH-Contract; Contract-099-72-0082; Chlorinated-hydrocarbons; Humans; Hematology; Blood-disorders; Toxicology; Behavior;
CAS No.
75-09-2;
Publication Date
19731201
Funding Type
Contract;
Fiscal Year
1974
NTIS Accession No.
PB83-109710
NTIS Price
A06
Identifying No.
Contract-099-72-0082
Source Name
Medical College of Wisconsin, Department of Environmental Medicine, Milwaukee, WI., NIOSH Contract No. 099-72-0082, 82 pages, 17 references
State
WI;
TOP