Effects of Methyl Butyl Ketone on Peripheral Nerves and its Mechanism of Action.
The effects of methyl-n-butyl-ketone (591786) (MBK) and methyl-ethyl- ketone (78933) (MEK) on the peripheral nerves of rats were studied. Wistar-rats inhaled 60 to 1050 parts per million (ppm) of MBK or 1460 to 4740ppm of MEK for 6 hours per day, 5 days per week for 4 to 6 weeks; rats were exposed to MBK until overt signs of neuropathy were evident. Electrophysiological, biochemical, and morphological examinations were performed. No animals exposed to MBK or MEK developed overt neuropathy by 6 weeks. Clinical signs of neuropathy became noticable at 9 to 10 weeks of MBK exposure. All MBK treated rats developed neuropathy by weeks 11 to 13. No neuropathic effects were seen in rats exposed to MEK. The authors conclude that MBK causes neuropathy while MEK does not.
NIOSH-Contract; Contract-099-76-0016; Laboratory-animals; Biochemical-analysis; Nervous-system-disorders; Toxicology; Organic-solvents;
NTIS Accession No.
Department of Neurology, Yale University School of Medicine New Haven, Conn. and Veterans Administration, Administration Hospital, West Haven, Conn., NIOSH Contract No. 099-76-0016, 41 pages, 45 references