Effect of Metopirone Upon Guinea Pig Response to Intratracheal BeO.
NIOSH 1972 May:18 pages
The effect of metopirone (908350) on beryllium disease was studied. Adult guinea-pigs received intratracheal injections of 2 milligrams of beryllium-oxide (1304569) (BeO). After 30 days a metopirone pellet was subcutaneously implanted for 3 days to induce adrenal imbalance; comparison animals received cholesterol pellets. Animals were sacrificed at various times and histopathologic examinations were performed. No important differences in adrenals or livers were seen. Prominent atelectasis was found in the lungs of metopirone treated animals. Hemosiderosis was seen in spleens of metopirone treated animals. The author concludes that metopirone appears to be associated with hemosiderosis of the spleen and atelectasis of the lungs.
NIOSH-Contract; Contract-099-71-0015; Laboratory-animals; Light-metals; Metallic-poisoning; Toxicology; Lung-disorders;
NTIS Accession No.
Pathology Services Associates, Belmont, California, NIOSH Contract No. 099-71-0015, 18 pages