Long- and short-term effects of carbaryl exposure in chick embryos.
Environ Res 1981 Dec; 26(2):463-471
The embryotoxic and teratogenic effects of carbaryl (63252) were investigated. Fertile White-Leghorn-chick eggs were injected with 1 to 10 milligrams (mg) of carbaryl in acetone or sesame oil, and were examined 5 or 12 days later. Embryo viability and the incidence of external malformations were recorded. Five days after treatment, mortality rates were increased in all embryos given carbaryl, and were greater in those given carbaryl in sesame oil than in those given carbaryl in acetone. No malformations were seen in any of the 5 day embryos. Mortality rates after 12 days were greater than those at 5 days. Malformations included subcutaneous edema, lower limb deformities, and one unilateral ophthalmia. The authors concludes that the embryotoxicity of carbaryl is affect by the vehicle in which it is administered. Carbaryl can be absorbed into the embryo after 5 days, but a longer time is required to cause teratogenic effects.
NIOSH-Publication; NIOSH-Grant; Carbamate-insecticides; Animal-studies; Reproductive-effects; Mortality-rates; Teratogenesis; Toxicology; Embryopathology; Congenital-effects
Anatomy Louisiana State University 1542 Tulane Avenue New Orleans, LA 70112
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana