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Effects of trichloroethylene on behavorial performance capabilities.

Authors
Stewart-RD; Hake-CL; Lebrun-AJ; Kalbfleisch-JH; Newton-PE; Peterson-JE; Cohen-HH; Struble-R; Busch-KA
Source
NIOSH 1973 Nov; :1-49
Link
NIOSHTIC No.
00118716
Abstract
The effects of trichloroethylene (79016) (TCE) on behavioral and cognitive performance were investigated. Nine volunteers were exposed for 8 hours per day for 3 days to 0.50, and 110 parts per million (ppm) of TCE; each exposure session was separated by a 4 day nonexposure period. Breath samples were taken at selected postexposure intervals for TCE and metabolite analysis. During the first and last hour of each exposure session, subjects completed complex reaction time, tachistoscopic perception, digit span, finger dexterity, flanagan coordination, and digit inspection tests. Subjective responses to exposure were also determined. The subjects reported various symptoms including headache, dizziness, and eye, nose and throat irritation. TCE exposure significantly affected performance only on the flanagan coordination test. Sources of variability on the other tests included learning effects, time of day, and subject. Results of breath analyses were not evaluated. The authors note these findings do not substantiate the positive results in a previous study of subjects exposed to 110ppm of TCE. They suggest that the discrepancy could be due to statistical methods, control of exposure concentrations, and exposure design.
Keywords
NIOSH-Contract; Contract-099-72-0084; Organic-solvents; Humans; Behavioral-tests; Task-performance; Behavior
CAS No.
79-01-6
Publication Date
19731101
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1974
NTIS Accession No.
PB82-230152
NTIS Price
A04
Identifying No.
Contract-099-72-0084
Source Name
National Institute for Occupational Safety and Health
State
WI
Performing Organization
The Medical College of Wisconsin, Department of Environmental Medicine
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