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Aflatoxin inhibition of viral interferon induction.

Authors
Hahon-N; Booth-JA; Stewart-JD
Source
Antimicrob Agents Chemother 1979 Sep; 16(3):277-282
NIOSHTIC No.
00118205
Abstract
The inhibitory effect of aflatoxin on interferon induction by influenza was investigated. Rhesus-monkey cells from the LLC-MK2 line were exposed to 1 to 100 micrograms of aflatoxin-B1 (1162658), aflatoxin-G1 (1165395), aflatoxin-B2 (7220817), or aflatoxin-G2 (7241987), plus 1 milliliter of influenza virus. Interferon induction was determined. Interferon induction was inhibited by all four aflatoxins in the following order of decreasing potency: B1, G1, B2, G2. Aflatoxin-B1 caused the greatest decreases in cell growth and viability in confluent cultures. Cells treated with aflatoxin induced greater influenza virus growth than did normal cells. Aflatoxin did not alter the ability of interferon to aid in the cellular resistance against viral infection, and did not affect viral infectivity or replication. The authors conclude that the inhibition of interferon induction by aflatoxin may be responsible for decreasing resistance to viral infections.
Keywords
NIOSH-Author; Toxins; Mammalian-cells; Infectious-diseases; Viral-diseases; Cellular-reactions
CODEN
AMACCQ
CAS No.
1162-65-8; 1165-39-5; 7220-81-7; 7241-98-7
Publication Date
19790901
Document Type
Journal Article
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0066-4804
NIOSH Division
ALOSH
Source Name
Antimicrobial Agents and Chemotherapy
State
WV
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